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The review aims to summarize current evidence regarding the management of periprosthetic joint infections (PJI).

June 19, 2026AntibioticsOpen Access

Management of Periprosthetic Joint Infections: A Multidisciplinary Approach

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The review aims to summarize current evidence regarding the management of periprosthetic joint infections (PJI).
Integrated overview of pathophysiology, risk factors, and microbiological patterns associated with PJI.
Evaluation of contemporary diagnostic pathways based on MSIS/ICM criteria and emerging biomarkers.
Discussion of medical and surgical treatment strategies, including debridement and organism-directed therapy.
Evidence of significant morbidity and increased healthcare costs associated with PJI.
Identification of diagnostic gaps in managing culture-negative infections and antimicrobial resistance.
Emphasis on the need for interdisciplinary collaboration and ongoing high-quality clinical research.

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Review outlines a multidisciplinary approach to manage periprosthetic joint infections, indicating important gaps and future directions.

Jeyaraman et al. (2026) studied this question.

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