Review highlights how sedentary behaviour affects health, drawing on extensive evidence and cultural insights.
For the first time in human evolutionary history, the majority of people in developed and developing economies spend most of their waking hours sitting. The human body evolved over approximately 1.8 million years for a life of sustained physical movement — walking, climbing, carrying, squatting, and performing thousands of small physical actions daily. Modern sedentary behaviour is therefore not simply an inconvenience or a lifestyle preference. It is a biological mismatch with profound consequences for metabolic health, cardiovascular function, musculoskeletal integrity, mental health, and longevity. This article reviews the epidemiological and physiological evidence on sedentary behaviour, drawing on research from the World Health Organization, the American Journal of Epidemiology, and landmark cohort studies showing that prolonged sitting is independently associated with increased risk of type 2 diabetes, cardiovascular disease, all-cause mortality, and depressive disorders — regardless of other exercise performed. The article examines the specific mechanisms through which sedentary behaviour disrupts insulin signalling, reduces lipoprotein lipase activity, increases systemic inflammation, and impairs neuroplasticity. It also investigates the ancient Indian understanding of movement as integral to health — from Ayurvedic texts prescribing daily physical activity to the movement principles embedded in yoga science. The article concludes with evidence-based strategies for breaking the sedentary pattern, arguing that the solution is not a gym membership but a fundamental redesign of how we relate to our bodies throughout the day.
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Narayan Rout (2026) studied this question.
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