Early Feasibility of Registration of Micro‐ PET / CT Scans to Annotated 3D Specimen Models

June 16, 2026Head & NeckOpen Access

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To evaluate the feasibility of correlating micro-PET/CT margin distances with histopathology using 3D specimen models.
Micro-PET/CT uptake co-registered to 3D annotated models using principal component analysis and iterative closest point registration.
Margin distances on fused models measured with Gaussian Mixed Modeling and compared with histopathology.
Analyzed data from five patients with head and neck cancer.
15 out of 16 margins measured on fused models were within 1 mm of histopathology.
Bland-Altman plot showed excellent agreement with a range of ±1.25 mm.
The technique demonstrates potential for intraoperative margin assessment in head and neck cancer.

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Shows high correlation of micro-PET/CT margin distances with histopathology in head and neck cancer, suggesting viability for clinical use.

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Austerlitz et al. (2026) studied this question.

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