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Demonstrates high accuracy for detecting cancer-derived exosomes, suggesting broad bioanalytical applications.
@Au nanoprobes, under near-infrared excitation, produce an anti-Stokes emission that overlaps with the vibronic bands of the tagged 4-mercaptopyridine (4-Mpy). Benefiting from this cooperative piezoelectric-photonic mechanism, our platform achieves ultrasensitive detection as low as 40 particles/mL while enabling highly accurate classification (≥98%) of cancer-derived exosomes. This work paves a promising way for developing regulated SERS platforms with broad potential for diverse bioanalytical applications beyond cancer-derived exosome detection.
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Dai et al. (2026) studied this question.
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