Knowledge, Attitude, and Perception of Clinical Trials among Cancer Patients in India: A Single-Center Cross-Sectional Study

Cancer is the leading cause of death globally and its incidence keeps increasing annually. Clinical trials (CTs) hold massive prospects to benefit patients, optimize treatment strategies, and improve evidence-based medical practice. To assess the present levels of knowledge, attitude, and perception of CTs among cancer patients. A cross-sectional study was conducted in the tertiary care center among cancer patients using a standardized self-administered questionnaire consisting of the domains—demographics, knowledge, attitude, and perception. A total of 679 cancer patients were invited to participate in the survey. Of these, 375 (n = 375) answered “yes” to the screening question and went on to complete the remaining 15 questions, which evaluated their knowledge, attitudes, and perceptions of CTs. This resulted in a final sample size of 375 participants, reflecting that 55.2% had an understanding of CTs. A total of 311 (82.9%) patients recognized that CT participation is voluntary. Additionally, 307 (81.9%) participants were open to the idea of engaging in CT if required in the future, whereas 290 (77.3%) were apprehensive of the potential risks that may be associated with the CT. The study provides valuable insights into the factors that affect the understanding of CTs among cancer patients and highlights the positive attitude and perception, while significant gaps remain in awareness and actual participation, along with the understanding of the ethical conduct of CTs. Targeted educational initiatives, physician involvement, community-based advocacy, and culturally focused communication strategies are essential to bridge these gaps.