Demonstrates enzymatic synthesis of complex spirotetronates, suggesting new biocatalytic routes.
biotransformations. The X-ray crystal structure of ChlE3 reveals the molecular basis of decalin formation by this enzyme. Harnessing this enzymatic cascade in biocatalysis could provide a valuable biomimetic route to both natural and non-natural spirotetronates, and the work described herein lays the foundation for application of these enzymes in chemoenzymatic syntheses of complex products.
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Devine et al. (2026) studied this question.
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