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To characterize the novel HLA-DPB1*1810:01 allele and its differences from HLA-DPB1*04:01:01:01.

June 19, 2026HLAOpen Access

Characterisation of the Novel HLA‐DPB1*1810:01 Allele by Short‐Read Next Generation Sequencing

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To characterize the novel HLA-DPB1*1810:01 allele and its differences from HLA-DPB1*04:01:01:01.
Utilized short-read next generation sequencing for genetic analysis.
Focused on the comparison of specific alleles in exon 2.
Identified one non-synonymous change (CTG → CCG) in exon 2 of HLA-DPB1*1810:01 compared to HLA-DPB1*04:01:01:01.

Novel HLA-DPB1*1810:01 allele exhibits a unique non-synonymous change in exon 2, suggesting genetic diversity.

HLA-DPB1*1810:01 differs from HLA-DPB1*04:01:01:01 in exon 2 by one non-synonymous change (CTG → CCG).

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Ryan et al. (2026) studied this question.

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Novel HLA-DPB1*1810:01 allele exhibits a unique non-synonymous change in exon 2, suggesting genetic diversity.

HLA-DPB1*1810:01 differs from HLA-DPB1*04:01:01:01 in exon 2 by one non-synonymous change (CTG → CCG).