What question did this study set out to answer?

This research evaluates the role of radiotherapy in managing relapsed or refractory classical Hodgkin lymphoma, particularly in the context of new therapies.

June 19, 2026Clinical and Translational Radiation OncologyOpen Access

Role of radiotherapy in refractory/relapsed classical Hodgkin lymphoma in the era of targeted therapies and immunotherapy

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Authors

SBSukeina BaouiaHôpital Saint-Louis RNRafik NebbacheHôpital Saint-Louis CBCôme BommierUniversité Paris Cité

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Implication

Randomized trial assesses radiotherapy outcomes in refractory classical Hodgkin lymphoma, suggesting enhanced local control.

Key Points

This research evaluates the role of radiotherapy in managing relapsed or refractory classical Hodgkin lymphoma, particularly in the context of new therapies.
Analyzed the impact of radiotherapy on local control of disease in the peri-transplant setting for eligible patients.
Reviewed data on outcomes of radiotherapy used alongside brentuximab vedotin and PD-1 inhibitors.
Considered modern radiotherapy techniques for improved treatment efficacy and tissue sparing.
Radiotherapy provides excellent local control for select patients with residual disease pre-transplant.
Limited evidence supports RT's efficacy when used after novel agents, mainly from small retrospective studies.
Combination of RT with PD-1 inhibitors shows promising efficacy signals, highlighting the need for further research.

Cite This Study

Baouia et al. (2026) studied this question.

synapsesocial.com/papers/6a34dfcd65a5b0777af2ec89 https://doi.org/10.1016/j.ctro.2026.101221

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Role of radiotherapy in refractory/relapsed classical Hodgkin lymphoma in the era of targeted therapies and immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Role of radiotherapy in refractory/relapsed classical Hodgkin lymphoma in the era of targeted therapies and immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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