What question did this study set out to answer?

This study examines the relationship between the sFlt-1/PlGF ratio and both maternal and neonatal outcomes in low-risk term pregnancies.

June 19, 2026Journal of Clinical MedicineOpen Access

Beyond Diagnostic Cut-Offs: Associations Between the sFlt-1/PlGF Ratio and Perinatal Outcomes in Low-Risk Term Pregnancies

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Authors

KBKarolina Bednarz MMMaisa Manasar-Dyrbuś MSMarcin Sadłocha

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Overview

Prospective cohort study investigates sFlt-1/PlGF ratio associations with maternal and neonatal outcomes, suggesting implications for placental health.

Key Points

This study examines the relationship between the sFlt-1/PlGF ratio and both maternal and neonatal outcomes in low-risk term pregnancies.
Prospective cohort study of 87 women with singleton term pregnancies
Measured serum sFlt-1 and PlGF at admission before delivery
Used multivariable regression models to analyze associations with maternal and neonatal outcomes.
Doubling of the sFlt-1/PlGF ratio increased estimated peripartum blood loss by 78.0 mL (95% CI 42.1–113.9; p < 0.001)
Higher ratio correlated with a postpartum hemoglobin decline of 0.078 g/dL (95% CI 0.008–0.148; p = 0.030)
Each doubling of the ratio was linked to a decrease in neonatal birthweight of 64.6 g (95% CI −102.0 to −27.2; p = 0.001).

Cite This Study

Bednarz et al. (2026) studied this question.

synapsesocial.com/papers/6a34dfcd65a5b0777af2ecab https://doi.org/10.3390/jcm15124679

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June 19, 2026Journal of Clinical MedicineOpen Access

Beyond Diagnostic Cut-Offs: Associations Between the sFlt-1/PlGF Ratio and Perinatal Outcomes in Low-Risk Term Pregnancies

View Full Paper

Ask AI

Bookmark

Authors

KBKarolina Bednarz MMMaisa Manasar-Dyrbuś MSMarcin Sadłocha

Discussion

Member takes

Overview

Prospective cohort study investigates sFlt-1/PlGF ratio associations with maternal and neonatal outcomes, suggesting implications for placental health.

Key Points

This study examines the relationship between the sFlt-1/PlGF ratio and both maternal and neonatal outcomes in low-risk term pregnancies.
Prospective cohort study of 87 women with singleton term pregnancies
Measured serum sFlt-1 and PlGF at admission before delivery
Used multivariable regression models to analyze associations with maternal and neonatal outcomes.
Doubling of the sFlt-1/PlGF ratio increased estimated peripartum blood loss by 78.0 mL (95% CI 42.1–113.9; p < 0.001)
Higher ratio correlated with a postpartum hemoglobin decline of 0.078 g/dL (95% CI 0.008–0.148; p = 0.030)
Each doubling of the ratio was linked to a decrease in neonatal birthweight of 64.6 g (95% CI −102.0 to −27.2; p = 0.001).

Cite This Study

Bednarz et al. (2026) studied this question.

synapsesocial.com/papers/6a34dfcd65a5b0777af2ecab https://doi.org/10.3390/jcm15124679

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