Injectable Gelatin-PEG Hydrogels Obtained via Cytochrome C-mediated Polymerization

Andrea Fumaneri; Edoardo Sisti; Alessandro Ajò; H. Samet Varol; Viola Bertolotti; Luigi Menduti; Luisa De Cola

doi:10.1039/d6ob00479b

January 1, 2026Organic & Biomolecular Chemistry

Injectable Gelatin-PEG Hydrogels Obtained via Cytochrome C-mediated Polymerization

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Key Points

This research aims to develop injectable hydrogels with rapid gelation for surgical applications and drug delivery.
Developed hydrogels using cytochrome C for polymerization.
Evaluated hydrogel properties under physiological conditions.
Investigated drug encapsulation efficiency and release kinetics.
Hydrogels showed rapid gelation times under in situ conditions, enhancing surgical applicability.
Achieved over 80% encapsulation efficiency for various drugs tested, with controlled release profiles.

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Implication

Demonstrates effective drug delivery using injectable hydrogels, suggesting a new method for surgical applications.

Abstract

Injectable hydrogels, capable of rapid in situ gelation under physiological conditions, are highly attractive for minimally invasive surgery and locoregional drug delivery. However, the wide majority of polymeric systems rely...

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Fumaneri et al. (2026) studied this question.

synapsesocial.com/papers/6a34dfcd65a5b0777af2ecf2 https://doi.org/10.1039/d6ob00479b

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Injectable Gelatin-PEG Hydrogels Obtained via Cytochrome C-mediated Polymerization

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Injectable Gelatin-PEG Hydrogels Obtained via Cytochrome C-mediated Polymerization

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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