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Identifies neutralizing autoantibodies in young individuals with cystic fibrosis, suggesting implications for mucosal pathology.
Groen et al. identify neutralizing interferon-λ2/3 autoantibodies in 11.8% of individuals with cystic fibrosis, a greater than 10-fold higher prevalence than in control individuals. Autoantibody-containing plasmas enhanced respiratory virus replication in vitro, and associated with allergic rhinitis in patients, suggesting that interferon-λ2/3 autoantibodies have the potential to impact mucosal pathology.
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Groen et al. (2026) studied this question.
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