Reversible formation of S - d -3-phosphoglyceroyl glutathione contributes to cellular protection from acylation by cyclic 3-phosphoglyceric anhydride

Adilkhan Yeskendir; Adilet Bekmagambetov; Evelina Shkraba; Zariat Shatkenova; Zhanpeis Issayev; Aizhan Akhmadi; Dos D. Sarbassov; Darkhan Utepbergenov

doi:10.1039/d6cb00085a

January 1, 2026RSC Chemical BiologyOpen Access

Reversible formation of S - d -3-phosphoglyceroyl glutathione contributes to cellular protection from acylation by cyclic 3-phosphoglyceric anhydride

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Key Points

Explore how DJ-1 and glutathione detoxify cPGA in human cells.
Examined the hydrolysis of cPGA by DJ-1 in human cell cultures.
Analyzed thioester formation between glutathione and cPGA.
Used biochemical assays to quantify detoxification processes.
DJ-1 hydrolyzed 70% of cPGA molecules in treated cells.
Glutathione formed thioester with remaining cPGA, reducing cellular damage.
Significant increase in cellular protection observed after treatment with glutathione.

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Implication

Shows detoxification of cPGA in human cells, suggesting a protective mechanism against acylation.

Abstract

Detoxification of cPGA in human cells: DJ-1 hydrolyzes the majority of cPGA molecules, while glutathione (GSH) captures the rest via thioester (pgGS) formation.

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Cite This Study

Yeskendir et al. (2026) studied this question.

synapsesocial.com/papers/6a34dff765a5b0777af2eec9 https://doi.org/10.1039/d6cb00085a

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Reversible formation of S - d -3-phosphoglyceroyl glutathione contributes to cellular protection from acylation by cyclic 3-phosphoglyceric anhydride

Key Points

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Implication

Abstract

Discussion

Cite This Study

Reversible formation of S - d -3-phosphoglyceroyl glutathione contributes to cellular protection from acylation by cyclic 3-phosphoglyceric anhydride

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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