Volumetric properties of some acetanilide derivatives in aqueous-ethanolic mixtures at different concentrations

Densities of dilute solutions of acetanilide, acetaminophen and phenacetin were measured as a function of molal drug concentration in some {ethanol (1) + water (2)} mixtures and neat ethanol (1) at T/K = 298.15 and T/K = 313.15. From these density values, apparent molar volumes, limiting apparent molar volumes and SV parameters of drug concentration-dependence of apparent molar volumes, limiting molar transfer properties, and limiting molar volumes of some substituent groups, were calculated and the results were interpreted in terms of structural effects, and possible solute-solvent interactions.