Key result
Valvular interstitial cells cultured on collagen and fibronectin were resistant to calcification, whereas cultures on fibrin, laminin, and heparin had a high number of calcified nodules.
The composition of the extracellular matrix significantly influences the calcification of valvular interstitial cells in vitro, which has implications for heart valve tissue engineering and understanding valvular disease mechanisms.
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May guide ECM selection in valve tissue engineering scaffolds; leaves open in vivo translation to reduce calcification.
Rodriguez et al. (2008) studied Valvular interstitial cell calcification. Extracellular matrix (ECM) components was evaluated on Number and size of calcific nodules and expression of mineralization markers (ALP and CBFa1). Valvular interstitial cells cultured on collagen and fibronectin were resistant to calcification, whereas cultures on fibrin, laminin, and heparin had a high number of calcified nodules.
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