Key result
Weight loss is linked to a ~33% increase in aortic distensibility and reduced ventricular masses.
Why the study?
Obesity is associated with cardiac hypertrophy, diastolic dysfunction, and increased aortic stiffness, but whether these cardiovascular responses are reversible during weight loss by bariatric surgery or diet remained to be tested.
Does weight loss via diet or bariatric surgery improve cardiac hypertrophy, diastolic dysfunction, and aortic stiffness in obese persons without comorbidities?
Comparison
Diet vs bariatric surgery vs continued obesity vs normal-weight controls
Design
Observational cohort study
Follow-up
1 year
Authors
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Weight loss may reverse cardiac changes in uncomplicated obesity; leaves open optimal approach and durability in larger trials.
Observational (n=57)
Does weight loss via diet or bariatric surgery improve cardiac hypertrophy, diastolic dysfunction, and aortic stiffness in obese persons without comorbidities?
Absolute Event Rate: 6.8% vs 5.1%
p-value: p=<0.001
Weight loss via diet or bariatric surgery over 1 year partially reverses cardiac hypertrophy, diastolic dysfunction, and aortic stiffness in obese individuals without other comorbidities.
Rider et al. (2009) conducted an observational in Obesity (n=57). Weight loss (bariatric surgery or diet) vs. Continued obesity (baseline or no weight loss) was evaluated on Cardiac hypertrophy, diastolic dysfunction, and aortic distensibility (p=<0.001). One year of weight loss by diet or bariatric surgery significantly increased distal descending aorta distensibility (from 5.1 to 6.8 mm Hg(-1) x 10(-3); p<0.001) and reduced ventricular masses.
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