Key result
Inflammatory bowel disease independently increases ASCVD risk, warranting enhanced prevention beyond traditional risk scores.
This review highlights IBD as an independent risk factor for ASCVD and discusses the challenges of risk management and primary prevention in this population.
Chronic inflammatory diseases including human immunodeficiency virus infection, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus predispose to atherosclerotic cardiovascular disease (ASCVD). Inflammatory bowel disease (IBD) is a common chronic inflammatory condition, and the United States has the highest prevalence worldwide. IBD has so far been overlooked as a contributor to the burden of ASCVD among young and middle-age adults, but meta-analyses of cohort studies suggest that IBD is an independent risk factor for ASCVD. This review discusses the epidemiological links between IBD and ASCVD and potential mechanisms underlying these associations. ASCVD risk management of patients with IBD is challenging because of their young age and the inability of current risk scores to fully capture their increased risk. The role of IBD in current primary prevention guidelines is evaluated, and strategies for enhanced ASCVD risk reduction in patients with IBD are outlined. Finally, the authors discuss knowledge gaps and future research directions in this innovative field.
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Cainzos‐Achirica et al. (2020) conducted a review in Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease. Inflammatory bowel disease was evaluated. Inflammatory bowel disease is an independent risk factor for atherosclerotic cardiovascular disease, requiring enhanced risk management strategies beyond current traditional risk scores.
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