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June 15, 2024Expert Opinion on Investigational Drugs55 citations

VERVE-101, a CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol

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AHAmanda J. HooperXTXuan TangJBJohn R. Burnett

Key Result

VERVE-101 is a CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol.

Structured PICO

Does VERVE-101 permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol?

I
Intervention
VERVE-101 (CRISPR base-editing therapy targeting hepatic PCSK9)
O
Outcome
Reduction in LDL-cholesterolsurrogate

VERVE-101 is a novel CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and lower LDL-cholesterol.

Abstract

Just over two decades ago, a new member of the secretory subtilase family, neural apoptosis-regulated convertase 1 (NARC-1), now known as proprotein convertase subtilisin/kexin type 9 (PCSK9), w...

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Cite This Study

Hooper et al. (2024) studied this question. VERVE-101 is a CRISPR base-editing therapy designed to permanently inactivate hepatic PCSK9 and reduce LDL-cholesterol.

synapsesocial.com/papers/6a356e3cb4dd3b69249ed4d9https://doi.org/10.1080/13543784.2024.2369747
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1VERVE-101: a promising CRISPR-based gene editing therapy that reduces LDL-C and PCSK9 levels in HeFH patients2023 · 79 citations
  2. 2In Vivo Base Editing of <i>PCSK9</i> with VERVE-102 for Hypercholesterolemia2026 · 21 citations
  3. 3Proprotein convertase subtilisin/kexin Type 9 inhibitors: past, present, and future2026 · 4 citations
  4. 4The evolving therapeutic landscape of PCSK9 inhibition2026 · 4 citations
  5. 5New developments in proprotein convertase subtilisin–kexin 9's biology and clinical implications2016 · 44 citations