Key result
TAVR linked to ~51% lower in-hospital mortality vs SAVR in dialysis patients with severe aortic stenosis.
Why the study?
Comparative outcomes between TAVR and SAVR continue to remain unclear in high-risk patients with severe aortic stenosis and chronic kidney disease undergoing dialysis.
Does TAVR improve postoperative clinical outcomes compared to SAVR in patients with severe AS and CKD undergoing dialysis?
Meta-Analysis (n=28,625)
Does TAVR improve postoperative clinical outcomes compared to SAVR in patients with severe AS and CKD undergoing dialysis?
Odds Ratio: 0.49 (95% CI 0.29–0.84)
p-value: p=0.01
In patients with severe AS and CKD on dialysis, TAVR is associated with lower in-hospital mortality and shorter length of stay compared to SAVR, despite a higher risk of permanent pacemaker implantation.
No takes yet. Share an insight, caveat, or question.
TAVR was associated with lower in-hospital mortality; leaves open selection bias and requires randomized confirmation before practice change.
Mylavarapu et al. (2026) conducted a meta-analysis in Severe aortic stenosis and chronic kidney disease undergoing dialysis (n=28,625). Transcatheter aortic valve replacement (TAVR) vs. Surgical aortic valve replacement (SAVR) was evaluated on in-hospital mortality (OR 0.49, 95% CI 0.29-0.84, p=0.01). TAVR was associated with significantly lower odds of in-hospital mortality compared to SAVR in patients with severe aortic stenosis and CKD on dialysis (OR 0.49; 95% CI 0.29-0.84; p=0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: