June 19, 2026Cardiology in the Young0 citations
View Full PaperSystolic anterior motion of an anomalous papillary muscle in obstructive hypertrophic cardiomyopathy
Key Result
A pathogenic MYBPC3 gene mutation in a child caused progression to severe obstructive hypertrophic cardiomyopathy with dynamic outflow obstruction from abnormal papillary muscle insertion.
Key Points
- To assess the implications of an MYBPC3 gene mutation on obstructive hypertrophic cardiomyopathy in a child.
- Case report of a child with MYBPC3 mutation
- Subvalvular assessment prior to surgical intervention
- Child progressed from normal to severe obstructive hypertrophic cardiomyopathy
- Dynamic outflow obstruction identified due to septal hypertrophy and abnormal papillary muscle insertion
Structured PICO
P
Population
A child with a pathogenic MYBPC3 gene mutation and obstructive hypertrophic cardiomyopathy
Highlights the importance of careful subvalvular assessment for surgical planning in pediatric patients with MYBPC3 mutations progressing to severe obstructive HCM.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
Abstract A child with a pathogenic MYBPC3 gene mutation progressed from normal to severe obstructive hypertrophic cardiomyopathy with dynamic outflow obstruction from septal hypertrophy and abnormal papillary muscle insertion, highlighting careful subvalvular assessment for surgical planning.