What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Parkinson's disease (n=40). Intervention: Parkinson's disease severity (MDS-UPDRS score). Primary outcome: Correlation between disease severity (MDS-UPDRS score) and sympathovagal balance (LF/HF ratio) (r = 0.965, p=<0.001).

What question did this study set out to answer?

To assess the correlation of cardiac autonomic function, cognitive parameters, and biochemical markers of cardiovascular risk and oxidative stress with disease severity in individuals with mild-to-moderate Parkinson's disease.

June 19, 2026CureusOpen Access

Association of Cardiac Autonomic Dysfunction and Cognitive Impairment With Disease Severity in Parkinson’s Disease: A Cross-Sectional Study

Q: What are the key findings of this study?

Increasing Parkinson's disease severity was significantly correlated with cardiac autonomic imbalance (LF/HF ratio r=0.965), cognitive impairment, and elevated oxidative stress markers.

Q: What does this research mean for the field?

Increasing Parkinson's disease severity is significantly correlated with cardiac autonomic imbalance, cognitive impairment, and elevated markers of cardiovascular risk and oxidative stress. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Q: What question did this study set out to answer?

To assess the correlation of cardiac autonomic function, cognitive parameters, and biochemical markers of cardiovascular risk and oxidative stress with disease severity in individuals with mild-to-moderate Parkinson's disease.

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Key result

Worsening Parkinson's disease strongly correlates with cardiac autonomic imbalance, cognitive impairment, and elevated oxidative stress.

r = 0.965
P<0.001
n=40

Why the study?

The relationship of cardiac autonomic imbalance and cognitive derangement with Parkinson's disease severity had not been explored using a multimodal approach.

Does disease severity in Parkinson's disease correlate with cardiac autonomic dysfunction, cognitive impairment, and biochemical markers?

Comparison

Correlation with disease severity measured by MDS-UPDRS Part III

Design

Cross-sectional study

Authors

UDUsha DhanaradjaJawaharlal Institute of Post Graduate Medical Education and Research RRRajasegaran RajalakshmiJawaharlal Institute of Post Graduate Medical Education and Research RARajeswari AghoramJawaharlal Institute of Post Graduate Medical Education and Research

Discussion

Member takes

Implication

Associations in Parkinson's should not yet alter practice; leaves open causal links and intervention targets for prospective studies.

Key Points

To assess the correlation of cardiac autonomic function, cognitive parameters, and biochemical markers of cardiovascular risk and oxidative stress with disease severity in individuals with mild-to-moderate Parkinson's disease.
Recruited 40 individuals aged 35 to 70 years with mild-to-moderate Parkinson's disease (mean age 57.1 ± 8.7 years; mean MDS-UPDRS score 41.1 ± 5.2).
Evaluated cardiac autonomic function via heart rate variability (HRV) and conventional tests, cognitive function via P300 event-related potentials and reaction times, and serum biomarkers (homocysteine and 8-OHdG) via ELISA.
Assessed relationships with motor severity (MDS-UPDRS Part III) using Pearson and Spearman's rank correlation coefficients.
Disease severity positively correlated with sympathetic HRV indices (LF power r=0.934, LF/HF r=0.965; P<0.001) and negatively correlated with parasympathetic indices (HF power r=-0.810, total power r=-0.799, pNN50 r=-0.433; P<0.05).
Cognitive testing demonstrated significant correlations with UPDRS scores for P300 latency (r=0.453, P=0.003), P300 amplitude (r=-0.953, P<0.001), red light visual reaction time (r=0.857, P<0.001), and tone auditory reaction time (r=0.964, P<0.001).
Serum biomarkers showed significant positive correlations with motor disease severity for homocysteine (Spearman r=0.862, P<0.001) and 8-OHdG (Spearman r=0.807, P<0.001).

Study Design

Type

Cross-Sectional (n=40)

Multicenter

Structured PICO

Does disease severity in Parkinson's disease correlate with cardiac autonomic dysfunction, cognitive impairment, and biochemical markers?

Population

40 adults aged 35 to 70 years with mild-to-moderate Parkinson's disease on stable therapy were evaluated in a cross-sectional study to assess systemic disease involvement.

Outcome

Correlation between cardiac autonomic function (HRV), cognitive parameters (P300 and reaction time), biochemical markers (HCY and 8-OHdG), and disease severity (MDS-UPDRS Part III)surrogate

Main Result

Effect estimate: r = 0.965

p-value: p=<0.001

Increasing disease severity in Parkinson's disease is associated with cardiac autonomic imbalance, cognitive impairment, and elevated markers of cardiovascular risk and oxidative stress.

Limitations

Cross-sectional study design precludes establishing causal relationships.
Absence of a healthy control group limits direct comparison with normative values.
Small sample size limits the generalizability of the findings.
Did not account for potential confounding variables such as age, gender, disease duration, medication use, and educational status.
Autonomic and cognitive assessments were not stratified according to ON/OFF medication states.

Cite This Study

Dhanaradja et al. (2026) conducted a cross-sectional in Parkinson's disease (n=40). Parkinson's disease severity (MDS-UPDRS score) was evaluated on Correlation between disease severity (MDS-UPDRS score) and sympathovagal balance (LF/HF ratio) (r = 0.965, p=<0.001). Increasing Parkinson's disease severity was significantly correlated with cardiac autonomic imbalance (LF/HF ratio r=0.965), cognitive impairment, and elevated oxidative stress markers.

synapsesocial.com/papers/6a35982fdd3be7785e70ed27 https://doi.org/10.7759/cureus.111116

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Association of Cardiac Autonomic Dysfunction and Cognitive Impairment With Disease Severity in Parkinson’s Disease: A Cross-Sectional Study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Association of Cardiac Autonomic Dysfunction and Cognitive Impairment With Disease Severity in Parkinson’s Disease: A Cross-Sectional Study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider