Key result
GAstV-2 strains drive ~20% mortality in goslings and demonstrate cross-species infection potential.
Why the study?
Public GAstV-2 sequencing data remain scarce, and its genetic evolution, pathogenic features, and cross-species transmission potential have not been fully elucidated.
Population
12 GAstV-2 strains from gout-affected goslings, plus goslings, ducks, and chickens
Comparison
Infection with GAstV-2 strains across different avian species
Design
Phylogenetic analysis and animal infection experimental study
Authors
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Indicates need for vigilance against GAstV-2 in multiple avian species; leaves open questions on control strategies.
GAstV-2 has evolved into two distinct lineages and demonstrates cross-species infection potential in geese, ducks, and chickens, causing histopathological lesions in multiple organs including the heart.
Liu et al. (2026) studied Goose astrovirus genotype 2 (GAstV-2) infection. Goose astrovirus genotype 2 (GAstV-2) inoculation was evaluated on Mortality and histopathological lesions. Goose astrovirus genotype 2 (GAstV-2) strains replicated efficiently in goslings, causing up to 20% mortality, and demonstrated cross-species infection potential in ducks and chickens.
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