Serum PGC-1α levels did not significantly change after aortic cross-clamping and were not associated with cross-clamp time, indicating that PGC-1α does not reflect acute ischemic duration in patients undergoing coronary artery bypass grafting.
Observational (n=44)
No
PGC-1α does not reflect ischemic duration or acute myocardial injury during CABG, but is independently associated with diabetes mellitus and ICU duration.
Absolute Event Rate: 1.43% vs 2.06%
p-value: p=0.608
Abstract Objectives This study aimed to evaluate whether peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) could serve as a marker of myocardial ischemia by examining its association with cross-clamp time, which reflects the duration of ischemia, in patients undergoing coronary artery bypass grafting (CABG). Methods The study included 44 adult patients who underwent open-heart surgery at the Cardiovascular Surgery Clinic between June 2024 and December 2024. Serum samples separated from the blood collected after cross-clamping and at the pump outlet were analyzed in our hospital’s central laboratory for the PGC-1α study. PGC-1α levels were analyzed in terms of clinical parameters, lactate and high-sensitivity cardiac troponin T (hs-cTnT) levels of the patients. Results Preoperative PGC-1α levels did not differ significantly from postoperative levels (2.06 ± 5.75 vs. 1.43 ± 3.35, p = 0.608), whereas hs-cTnT levels increased significantly after surgery ( p 0.05). In the multivariable analysis, DM (odds ratio OR = 3.060, p 0.05). Conclusion PGC-1α was not associated with cross-clamp time or conventional markers of acute myocardial injury in patients undergoing coronary artery bypass grafting, indicating that it does not reflect ischemic duration. In contrast, hs-cTnT levels were significantly associated with the cross-clamp time in non-diabetic patients, whereas this relationship was not observed in diabetic individuals. The association of PGC-1α with diabetes mellitus and ICU duration suggests that it may reflect metabolic status rather than acute myocardial injury.
Yıldız et al. (Fri,) conducted a observational in Myocardial ischemia-reperfusion injury (n=44). PGC-1α levels vs. Preoperative vs postoperative levels was evaluated on Change in serum PGC-1α levels before and after aortic cross-clamping (p=0.608). Serum PGC-1α levels did not significantly change after aortic cross-clamping and were not associated with cross-clamp time, indicating that PGC-1α does not reflect acute ischemic duration in patients undergoing coronary artery bypass grafting.
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