Why the study?
Male sex is a potential risk factor for worse outcomes in human myocarditis, but the role of sex in experimental autoimmune myocarditis has not been fully explored.
Does sex influence the inflammatory response, fibrosis formation, and cardiac function in an experimental autoimmune myocarditis rat model?
Population
Male and female rats with experimental autoimmune myocarditis
Comparison
Male vs female rats
Design
Animal experimental study
Follow-up
21 days
Authors
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Male-biased pro-inflammatory EAM phenotype cautions against unisex rodent models; leaves open sex-stratified human myocarditis mechanisms.
Does sex influence the inflammatory response, fibrosis formation, and cardiac function in an experimental autoimmune myocarditis rat model?
In an experimental autoimmune myocarditis model, male rats develop a pro-inflammatory phenotype with increased fibrosis and impaired cardiac function, whereas female rats exhibit an anti-inflammatory phenotype with preserved cardiac function.
Barcena et al. (2021) studied this question.
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