Key result
Twenty-four months of high-intensity exercise training in sedentary adults increased left atrial volume by 55% (P<0.0001) with no observed electric remodeling compared to controls.
Why the study?
Moderate-intensity exercise is associated with decreased atrial fibrillation risk, whereas extensive athletic training increases risk; the effects of 24 months of high-intensity exercise on left atrial mechanical and electric remodeling in sedentary middle-aged adults remained unclear.
Does 24 months of high-intensity exercise training induce left atrial mechanical and electric remodeling in sedentary middle-aged adults?
Comparison
Exercise training (10 months then 14 months maintenance) vs stretching/balance control
Design
Randomized controlled trial
Follow-up
24 months
Authors
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Substantial LA enlargement with prolonged exercise warrants monitoring in athletes; leaves open effects on function and arrhythmia risk.
RCT (n=75)
randomized
Does 24 months of high-intensity exercise training induce left atrial mechanical and electric remodeling in sedentary middle-aged adults?
p-value: p=<0.0001
Twenty-four months of high-intensity exercise training in sedentary middle-aged adults leads to disproportionate left atrial mechanical remodeling without electrical remodeling, suggesting a potential mechanism for exercise-induced atrial fibrillation.
McNamara et al. (2019) conducted an RCT in Sedentary, healthy middle-aged adults (n=75). High-intensity exercise training vs. Stretching/balance control was evaluated on Left atrial (LA) mechanical and electric remodeling (p=<0.0001). Twenty-four months of high-intensity exercise training in sedentary adults increased left atrial volume by 55% (P<0.0001) with no observed electric remodeling compared to controls.
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