Key result
Caseous calcification of the mitral annulus was associated with a significantly higher prevalence of cerebrovascular events compared to mitral annular calcification (19.2% vs 11.8%, OR 1.78).
Why the study?
Does caseous calcification of the mitral annulus increase the risk of cerebrovascular events compared to mitral annular calcification?
Population
130 patients with caseous calcification of the mitral annulus (CCMA) identified from 86 publications
Comparison
Caseous calcification of the mitral annulus vs Mitral annular calcification (MAC) (n=1818)
Design
Systematic_review
Authors
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CCMA may heighten cerebrovascular event risk versus mitral annular calcification; challenges benign prognosis assumption and leaves open need for prospective trials.
Systematic Review (n=1,948)
Does caseous calcification of the mitral annulus increase the risk of cerebrovascular events compared to mitral annular calcification?
Odds Ratio: 1.78 (95% CI 1.1278–2.8239)
Absolute Event Rate: 19.2% vs 11.8%
p-value: p=0.01796
CCMA is associated with a significantly higher risk of cerebrovascular events compared to MAC, challenging the belief that it has a benign prognosis and suggesting a potential role for elective surgical resection.
Dietl et al. (2016) conducted a systematic review in Caseous calcification of the mitral annulus (n=1,948). Caseous calcification of the mitral annulus (CCMA) vs. Mitral annular calcification (MAC) was evaluated on Cerebrovascular events (CVE) (OR 1.78, 95% CI 1.1278-2.8239, p=0.01796). Caseous calcification of the mitral annulus was associated with a significantly higher prevalence of cerebrovascular events compared to mitral annular calcification (19.2% vs 11.8%, OR 1.78).
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