Key result
10-year survivors of early breast cancer had a decreased risk of stroke compared with the general population (SIR 0.8; 95% CI 0.6-0.9), although hormonal treatment was associated with increased risk (HR 1.9).
Why the study?
Do specific breast cancer treatments increase the risk of cerebrovascular events in long-term survivors?
Cohort (n=4,414)
Do specific breast cancer treatments increase the risk of cerebrovascular events in long-term survivors?
Effect estimate: SIR 0.8 (95% CI 0.6 to 0.9)
Long-term breast cancer survivors do not have an increased overall risk of stroke compared to the general population, although tamoxifen use is associated with a higher risk.
No takes yet. Share an insight, caveat, or question.
May warrant stroke monitoring with hormonal therapy in survivors; leaves open net effects of contemporary regimens versus historical cohorts.
Hooning et al. (2006) conducted a cohort in Early breast cancer (n=4,414). Early breast cancer survivorship vs. General population was evaluated on Stroke (SIR 0.8, 95% CI 0.6 to 0.9). 10-year survivors of early breast cancer had a decreased risk of stroke compared with the general population (SIR 0.8; 95% CI 0.6-0.9), although hormonal treatment was associated with increased risk (HR 1.9).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: