A doubling of Systematic Coronary Risk Evaluation estimated risk was associated with increased odds of coronary artery calcium score >0 (OR 2.18; 95% CI 2.07-2.30) and >1 carotid plaques.
Cross-Sectional (n=13,411)
Is the Systematic Coronary Risk Evaluation (SCORE) algorithm associated with prevalent subclinical atherosclerosis in apparently healthy individuals?
The Systematic Coronary Risk Evaluation (SCORE) algorithm is significantly associated with prevalent subclinical atherosclerosis in the coronary and carotid arteries among apparently healthy individuals.
Odds Ratio: 2.18 (95% CI 2.07–2.3)
BACKGROUND: It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and prevalent subclinical atherosclerosis. DESIGN: The design of this study was as a cross-sectional analysis from a population-based study cohort. METHODS: From the general population, the Swedish Cardiopulmonary Bioimage Study randomly invited individuals aged 50-64 years and enrolled 13,411 participants mean age 57 (standard deviation 4.3) years; 46% males between November 2013-December 2016. Associations between Systematic Coronary Risk Evaluation risk estimates and coronary artery calcification and plaques in the carotid arteries by using imaging data from a computed tomography of the heart and ultrasonography of the carotid arteries were examined. RESULTS: Coronary calcification was present in 39.5% and carotid plaque in 56.0%. In men, coronary artery calcium score >0 ranged from 40.7-65.9% and presence of carotid plaques from 54.5% to 72.8% in the age group 50-54 and 60-65 years, respectively. In women, the corresponding difference was from 17.1-38.9% and from 41.0-58.4%. A doubling of Systematic Coronary Risk Evaluation was associated with an increased probability to have coronary artery calcium score >0 (odds ratio: 2.18 (95% confidence interval 2.07-2.30)) and to have >1 carotid plaques (1.67 (1.61-1.74)). CONCLUSION: Systematic Coronary Risk Evaluation estimated risk is associated with prevalent subclinical atherosclerosis in two major vascular beds in a general population sample without established cardiovascular disease or diabetes mellitus. Thus, the Systematic Coronary Risk Evaluation risk chart may be of use for estimating the risk of subclinical atherosclerosis.
Östgren et al. (Tue,) conducted a cross-sectional in Apparently healthy individuals (n=13,411). Systematic Coronary Risk Evaluation (SCORE) estimated risk was evaluated on Coronary artery calcium score >0 (OR 2.18, 95% CI 2.07-2.30). A doubling of Systematic Coronary Risk Evaluation estimated risk was associated with increased odds of coronary artery calcium score >0 (OR 2.18; 95% CI 2.07-2.30) and >1 carotid plaques.
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