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June 20, 2026Frontiers in Veterinary ScienceOpen Access

A narrative review of the clinical applications of tiletamine-zolazepam in canine and feline anesthesia

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Authors

THTzu-Yang HungJYJin YudongPSPaulo V. Steagall

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Overview

Narrative review highlights clinical applications and safety of tiletamine-zolazepam in dogs and cats, suggesting careful monitoring is essential.

Key Points

  • The aim is to review the pharmacology and clinical applications of tiletamine-zolazepam in canine and feline anesthesia.
  • Synthesized evidence regarding pharmacology, dosage regimens, and adverse effects of tiletamine-zolazepam.
  • Discussed various combinations with other anesthetics and their effects on dogs and cats.
  • Tiletamine-zolazepam provides rapid anesthesia onset but recovery varies by species.
  • Clinical dosages are often lower than recommended, particularly for intravenous use, requiring individual titration.
  • Contraindicated in animals with cardiorespiratory, hepatic, renal disease, or other specified conditions.

Cite This Study

Hung et al. (2026) studied this question.

synapsesocial.com/papers/6a362d32db0793dc1a535a8ehttps://doi.org/10.3389/fvets.2026.1807278
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anaesthetic Evaluation of Various Combinations of Xylazine, Ketamine and Tiletamine-zolazepam in Dogs2024
  2. 2Tiletamine–Zolazepam Use in Exotic Pets and Wildlife Anesthesia: A Narrative Review Towards Practical Guidelines2026
  3. 3The efficacy and safety of the combination of tiletamine-zolazepam (Vezotil®) with dexmedetomidine for controlled sedation of dogs and cats during invasive mechanical ventilation: a pilot prospective randomized controlled trial2026
  4. 4Evaluation of Medetomidine Dose Variations on Tiletamine-Zolazepam and Tramadol Anesthetic Combination in Dogs2025 · 1 citations
  5. 5Evaluation of Medetomidine Dose Variations on Tiletamine-Zolazepam and Tramadol Anesthetic Combination in Dogs2025