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June 20, 2026American Journal of Case ReportsOpen Access

Single-Site ALK-Positive Histiocytosis With TFG-ALK Fusion: Expanding the Clinical Spectrum of This Rare Entity

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Authors

MDM DasguptaUniversity of Tennessee Health Science CenterDHDavid HorvathUniversity of Tennessee Medical CenterBBB T BevillUniversity of Tennessee Health Science Center

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Implication

Case report identifies single-site ALK-positive histiocytosis with TFG-ALK fusion, expanding its clinical understanding.

Key Points

  • To report the first case of single-site ALK-positive histiocytosis involving a TFG-ALK fusion and to expand the understanding of this rare entity.
  • A 50s male underwent imaging for lung cancer screening, revealing a solitary pulmonary nodule.
  • The nodule was surgically removed, and histopathologic evaluation confirmed a spindle cell neoplasm with ALK positivity.
  • Gene fusion analysis was conducted using Archer FusionPlex for TFG-ALK detection.
  • Histologic evaluation indicated a well-circumscribed spindle cell neoplasm expressing histiocytic markers.
  • TFG-ALK fusion was confirmed, distinguishing it from other ALK-rearranged neoplasms.
  • The patient remains disease-free with no systemic therapy following surgical intervention.

Cite This Study

Dasgupta et al. (2026) studied this question.

synapsesocial.com/papers/6a362d9ddb0793dc1a535c43https://doi.org/10.12659/ajcr.952807
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Case report: Systemic presentation of ALK-positive Histiocytosis2024 · 4 citations
  2. 2Multisystem ALK-positive histiocytosis: a multi-case study and literature review2023 · 31 citations
  3. 3DP14 ALK-positive histiocytosis with involvement confined to the skin: report of two cases in adults2024
  4. 4Case Report: ALK-positive histiocytosis with a novel PTRH2::ALK fusion masquerading as a liver abscess in an infant2026
  5. 5Localized episcleral ALK-positive histiocytosis: a novel adult presentation confirmed by ALK gene rearrangement2026