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June 20, 2026CureusOpen Access

Chronic Unilateral Proptosis in Primary Care: A Case of IgG4-Related Orbital Disease

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Authors

YSYaqeen M SahwanNANajlaa M Alsudairy

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Overview

Case report of IgG4-related orbital disease diagnosed after imaging suggested lymphoma, emphasizing diagnosis challenges.

Key Points

  • To highlight the diagnostic challenges of IgG4-related orbital disease in differentiating it from malignant conditions like orbital lymphoma.
  • Case report of a 50-year-old man with right-sided proptosis and imaging findings suggesting lymphoma.
  • Anterior orbitotomy and incisional biopsy performed to obtain tissue for histopathological analysis.
  • Histopathology revealing IgG4-positive plasma cells and increased IgG4/IgG ratio to confirm the diagnosis.
  • Histopathology confirmed IgG4-related orbital disease excluding malignancy based on lymphoplasmacytic infiltration.
  • Postoperative course was uneventful, facilitating follow-up for potential systemic involvement.
  • Findings emphasize the similarities between IgG4-ROD and orbital lymphoma, highlighting diagnostic challenges.

Cite This Study

Sahwan et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535d5fhttps://doi.org/10.7759/cureus.111046
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IgG4-related disease: a clinical perspective2019 · 180 citations
  2. 2IgG4-related disease for the hematologist2024 · 11 citations
  3. 3IgG4-related orbital disease: a meta-analysis and review2012 · 154 citations