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June 20, 2026BMC GastroenterologyOpen Access

Identification of potential biomarkers for ulcerative colitis based on multidimensional data analysis and investigation of the mechanisms of therapeutic effects

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Authors

余余淑娇QZQ. M. ZhuCYChengdong Yu

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Overview

Randomized trial identifies biomarkers in ulcerative colitis, revealing curcumin's role in reducing inflammation.

Key Points

  • To identify potential biomarkers for ulcerative colitis and investigate therapeutic effects of curcumin chitosan microspheres.
  • Differential expression analysis using limma package (|log2FC| > 1, corrected P < 0.05)
  • Weighted gene coexpression network analysis and three machine learning algorithms (LASSO, random forest, SVM-RFE)
  • Construction of UC mouse model and application of curcumin chitosan microspheres
  • Four core genes identified: FCN3, FGR, HSD11B1, PIM2
  • CCM treatment improved pathological damage and reduced inflammatory factor levels in UC mice
  • Protein expression levels of FCN3, FGR, HSD11B1, PIM2 were inhibited in colon tissue after CCM treatment

Cite This Study

余淑娇 et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535e97https://doi.org/10.1186/s12876-026-05005-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-omics integration analysis based on plasma circulating proteins reveals potential therapeutic targets for ulcerative colitis2025
  2. 2Identification and immunoinfiltration analysis of key genes in ulcerative colitis using WGCNA2024 · 5 citations
  3. 3Identification and validation of coagulation and fibrinolytic-related diagnostic biomarkers for ulcerative colitis by bioinformatics analysis2024 · 2 citations
  4. 4Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model2026
  5. 5Predicting novel biomarkers for early diagnosis and dynamic severity monitoring of human ulcerative colitis2024 · 7 citations