κ-Carrageenan-Based Hydrogels Support Viability and Odontogenic Differentiation of Stem Cells From the Apical Papilla

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Key Points

This study aims to assess how κ-carrageenan-based hydrogels influence the viability and differentiation of stem cells from the apical papilla.
Hydrogels were formulated with varying concentrations of κ-carrageenan and gelatin.
Physicochemical characterization included properties like swelling and degradation at multiple time points.
Cell viability and differentiation markers were assessed using various assays including alkaline phosphatase activity and qPCR.
All hydrogel formulations maintained cell viability, with 2.5% κ-carrageenan and gelatin showing the highest viability and mineralization activity.
Gene expression analysis indicated enhanced expression of dentin-pulp markers in the 2.5% κ-carrageenan-gelatin formulation.
Higher alkaline phosphatase activity and mineral deposition were observed in κ-carrageenan formulations, especially 2.5% κ-carrageenan-gelatin.

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Evaluates κ-carrageenan hydrogels' support for stem cells, highlighting regenerative potential.

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Alajlan et al. (2026) studied this question.

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