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June 20, 2026Journal of the International Society of Sports NutritionOpen Access

Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial

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Authors

TOTimothy E. O’TooleCWChristopher J. WingardSBSonja K. Bariess

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Overview

Randomized trial examines carnosine's impact on endurance in participants, highlighting potential age-related benefits.

Key Points

  • This study aims to evaluate the effects of carnosine supplementation on physical endurance and performance outcomes.
  • 299 participants were randomized to receive either placebo or 2 g/day carnosine for 12 weeks.
  • Physical performance was assessed using multiple tests before and after the supplementation period.
  • Blood and urine samples were collected at each clinical visit.
  • A significant increase in calf raises was observed in participants under 40 years (p=0.018).
  • For males over 40, a significant increase in steps was noted (p=0.010).
  • No significant differences were found in other performance measures between carnosine and placebo groups.

Cite This Study

O’Toole et al. (2026) studied this question.

synapsesocial.com/papers/6a362e1edb0793dc1a53601ehttps://doi.org/10.1080/15502783.2026.2679716
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beta-alanine (Carnosyn™) supplementation in elderly subjects (60–80 years): effects on muscle carnosine content and physical capacity2011 · 133 citations
  2. 2Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial2024 · 6 citations
  3. 3The Effects of Carnosine on Cognitive Function and Mental Health—A Systematic Review and Meta-Analysis2026
  4. 4Considerations for Carnosine Actions in Biology2026 · 1 citations
  5. 5Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation2021 · 107 citations