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June 20, 2026Poultry Science0 citationsOpen Access

Characterization and Pathogenicity of H6N6 Avian Influenza Virus in Ducks

Characterization and Pathogenicity of a Novel Triple-Reassortant H6N6 Avian Influenza Virus Associated with Reproductive Failure in Breeding Ducks

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Authors

PZPuduo ZhuLGLiguo GaoZLZhihong Luo

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Overview

Randomized trial reveals reproductive failure in breeding ducks due to H6N6 AIV, indicating serious impacts on duck farming.

Key Points

  • This research aims to characterize a novel H6N6 avian influenza virus and assess its pathogenicity in breeding ducks.
  • Conducted serological surveillance and virus isolation on breeding duck farms and live bird markets.
  • Performed phylogenetic analysis on the isolated H6N6 strain to determine its genetic origins.
  • Conducted in vivo challenge experiments in mice, SPF chickens, and Muscovy ducks to evaluate infection effects.
  • The novel H6N6 strain is confirmed as a triple-reassortant virus from three distinct genetic clades.
  • Key amino acid substitutions A138S and A222V were identified in the virus's hemagglutinin protein.
  • Infection in breeding ducks resulted in significant reproductive tract damage and a notable decrease in egg production.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a362e1edb0793dc1a53604chttps://doi.org/10.1016/j.psj.2026.107308
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