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April 18, 2026MicroorganismsOpen Access

Characterization and Genetic Evolution of H6N2 Subtype AIV Isolates from Aquatic Birds

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Authors

LDLulu DengTSTaif ShahYWYandaijiu Wang

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Overview

Research characterizes H6N2 avian influenza viruses in aquatic birds, suggesting risks for mammalian adaptation.

Key Points

  • The aim is to characterize the H6N2 subtype AIV isolates from aquatic birds and understand their genetic evolution.
  • Collected 619 avian samples from Jianhu Lake, Yunnan Province.
  • Isolated four H6N2 AIV strains from different bird species.
  • Conducted genomic analyses to determine genetic lineage and reassortment.
  • Performed in vitro assays on cell lines and in vivo infection models using BALB/c mice.
  • Isolated strains belong to the Eurasian lineage with complex reassortment origins.
  • JH-2-11 strain replicated efficiently in various cell lines.
  • Infected BALB/c mice demonstrated weight loss and severe respiratory tract lesions without mortality.

Cite This Study

Deng et al. (2026) studied this question.

synapsesocial.com/papers/69e3207940886becb653f9b6https://doi.org/10.3390/microorganisms14040895
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