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June 20, 2026Natural Product Research

A Labdane Diterpene from Hedychium coronarium rhizomes: in vitro antimicrobial activity and in silico multi-target docking against Staphylococcus aureus proteins

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Authors

NRN RabitaKPK. Palanisamy

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Overview

Randomized trial assesses antimicrobial effects of labdane diterpene in Staphylococcus aureus, suggesting potential therapeutic applications.

Key Points

  • This research explores the antimicrobial properties and phytochemical composition of a labdane diterpene from Hedychium coronarium rhizomes.
  • Conducted qualitative and quantitative phytochemical analyses on methanolic extract.
  • Performed bioassay-guided isolation followed by molecular docking analysis against Staphylococcus aureus proteins.
  • Utilized FT-IR and GC-MS techniques for structural determination and compound profiling.
  • The methanolic extract showed significant antimicrobial activity with a maximum inhibition zone of 28.73 mm against Staphylococcus aureus.
  • The isolated labdane diterpene exhibited enhanced antimicrobial activity with a zone of inhibition of 30.40 mm at lower concentrations.
  • Molecular docking revealed a high binding affinity of −9.46 kcal/mol with dihydrofolate reductase from Staphylococcus aureus.

Cite This Study

Rabita et al. (2026) studied this question.

synapsesocial.com/papers/6a362e62db0793dc1a5361cchttps://doi.org/10.1080/14786419.2026.2689490
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