Demonstrates enhanced inhibition of SARS-CoV-2 Macrodomain in cellular models, suggesting potential therapeutic pathways.
Coronavirus macrodomains (Mac1) counter host immunity by removing ADP-ribose. GS-441524, the parent nucleoside of remdesivir, inhibits SARS-CoV-2 Mac1, but its active metabolite and cellular engagement were undefined. GS-441524 selectively inhibits...
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Biswas et al. (2026) studied this question.
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