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June 20, 2026Cephalalgia

Is achieving higher standards in real-world migraine care feasible with anti-CGRP monoclonal antibodies preventive therapies?: Insights from the EUREkA cohort

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Authors

ECEdoardo CaronnaUniversitat Autònoma de BarcelonaRMRut Mas-de-les-VallsUniversitat Autònoma de BarcelonaGEGabriella EgeoVita-Salute San Raffaele University

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Overview

Randomized trial evaluates migraine prevention outcomes in adults using anti-CGRP monoclonal antibodies, suggesting improvements in treatment standards.

Key Points

  • Evaluate the effectiveness of anti-CGRP monoclonal antibodies in achieving migraine treatment goals in a real-world setting.
  • Prospective European multicenter study
  • Included 5818 adults with migraine treated with anti-CGRP antibodies
  • Assessed migraine control categories after 6 months of treatment.
  • 6.9% achieved migraine freedom after 6 months
  • 22.9% attained optimal control and 24.6% achieved modest control
  • 27.1% of those with insufficient control saw a ≥50% reduction in monthly migraine days.

Cite This Study

Caronna et al. (2026) studied this question.

synapsesocial.com/papers/6a362e91db0793dc1a536432https://doi.org/10.1177/03331024261440370
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Redefining migraine prevention: early treatment with anti-CGRP monoclonal antibodies enhances response in the real world2024 · 41 citations
  2. 2Real world effectiveness of anti-CGRP monoclonal antibodies over three consecutive one-year treatment cycles: An intention-to-treat analysis2025 · 5 citations
  3. 3Efficacy and safety of CGRP monoclonal antibodies in chronic migraine: a systematic review integrating randomized and real-world evidence2026
  4. 4Monoclonal antibodies targeting the calcitonin gene-related peptide pathway improve the effectiveness of acute medication—a real-world study2024 · 3 citations
  5. 5Cgrp Monoclonal Antibodies: Key Lessons from Real World Evidence2024 · 2 citations