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June 20, 2026Neuropsychology ReviewOpen Access

Health Outcomes Following Traumatic Brain Injury: An Umbrella Review

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Authors

JTJason M. ToliaoUniversity of Southern CaliforniaJLJ LeeUniversity of Southern CaliforniaHOHans OhUniversity of Southern California

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Overview

Umbrella review evaluates comorbid health outcomes of traumatic brain injury in a large global cohort, highlighting methodological issues.

Key Points

  • This review investigates the link between traumatic brain injury and various comorbid health outcomes while assessing the quality of related studies.
  • Umbrella review of systematic reviews and meta-analyses assessing health outcomes following TBI.
  • Screening of literature from databases including EMBASE, PubMed, and MEDLINE.
  • Quality assessment of included studies using AMSTAR2 criteria.
  • 41 meta-analyses included, covering 671 original studies and 53 comorbid health outcomes, totaling 83 million participants.
  • Findings indicate associations of TBI with impairments in neurological, cognitive, mental health, and behavioral areas.
  • 78% of included studies were rated with 'critically low' methodological quality, limiting causal inferences.

Cite This Study

Toliao et al. (2026) studied this question.

synapsesocial.com/papers/6a362e91db0793dc1a5364achttps://doi.org/10.1007/s11065-026-09704-x
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