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June 20, 2026JNCI Journal of the National Cancer Institute

Heterotransplantation of Human Malignant Tumors in “Nude” Thymusless Mice. I. Breeding and Maintenance of “Nude” Mice

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Authors

BGB.C. GiovanellaJSJ. S. StehlinSt. Joseph Hospital

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Implication

Randomized trial examines breeding and maintenance of pathogen-free nude mice for tumor studies, suggesting effective protocols.

Key Points

  • The aim is to establish a breeding and maintenance protocol for nude mice to facilitate tumor transplantation studies.
  • 133 nude thymusless mice were bred in a sterile environment from heterozygote parents.
  • Antibiotics were administered in drinking water to ensure pathogen-free status.
  • Mice were kept under strict conditions to promote survival and avoid inbreeding.
  • Observed a low mortality rate of 5% during the study period.
  • Survival duration exceeded 10 months with no instances of wasting disease.
  • Large litters of robust outbred animals were obtained, suitable for heterotransplantation.

Cite This Study

Giovanella et al. (1973) studied this question.

synapsesocial.com/papers/6a362ebddb0793dc1a5365e6https://doi.org/10.1093/jnci/51.2.615
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