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June 20, 2026Clinical Journal of the American Society of NephrologyOpen Access

The Effect of Gender-Affirming Hormone Treatment on Kidney Function Trajectories in Transgender and Gender Diverse Veterans

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Authors

NJNicholas JacksonNBNeda BuljubasicKKKamyar Kalantar-Zadeh

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Overview

Longitudinal cohort study analyzes kidney function trajectories in transgender veterans, suggesting individualized monitoring is necessary.

Key Points

  • To compare serum creatinine levels and eGFR slopes in transgender individuals receiving hormone therapy versus cisgender controls.
  • Longitudinal cohort study of veterans from January 2006 to December 2019
  • Assessment of serum creatinine and eGFR using algorithms based on gender identity and sex assigned at birth
  • Generalized linear mixed effect models and two-way fixed effects models to evaluate kidney function changes.
  • Serum creatinine increased in transgender men by three months after hormone therapy initiation with stabilization by twelve months, while transgender women showed no significant changes.
  • eGFR was significantly lower in transgender men post hormone therapy initiation, whereas it remained stable in transgender women.

Cite This Study

Jackson et al. (2026) studied this question.

synapsesocial.com/papers/6a362ebddb0793dc1a536652https://doi.org/10.2215/cjn.0000001131
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kidney Health and Gender-Affirming Hormone Therapy for Transgender and Gender Diverse Individuals2025 · 2 citations
  2. 28483 Changes in kidney hemodynamics during gender-affirming hormone therapy in transgender individuals - findings from the KNIGHT pilot study2024
  3. 3Gender‐Affirming Hormone Therapy: Pharmacokinetic Considerations for Oncology in Transgender Patients2025
  4. 4Kidney transplantation in the transgender population: Lights and shadows2026
  5. 5Association Between Gender-affirming Hormone Therapy and Measures of Glucose Metabolism: A Longitudinal Study2024 · 3 citations