Concise Synthesis of Simplified Aogacillin Analogs Reveals Innate Reactivity and Synergy with Aminoglycosides

Andrew R. LeBlanc; Jacqueline R. Smith; Audrey J. Isakov; John Bacsa; William Wuest

doi:10.1039/d6sc04046b

January 1, 2026Chemical ScienceOpen Access

Concise Synthesis of Simplified Aogacillin Analogs Reveals Innate Reactivity and Synergy with Aminoglycosides

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Key Points

The aim is to investigate the synergy and reactivity of simplified aogacillin analogs with aminoglycosides.
Utilized simplified synthesis of aogacillin analogs from Simplicillium sp.
Assessed the synergistic effects with aminoglycoside antibiotics through experimental validation.
Identified enhanced antibacterial activity of simplified aogacillin analogs against drug-resistant strains.
Demonstrated significant synergism with aminoglycosides, enhancing their effectiveness.

Implication

Reveals enhanced synergism of aogacillin analogs with aminoglycosides, indicating potential for improved antibiotic therapies.

Abstract

Aogacillins (AOGs) A-B, two diastereomeric natural products isolated from Simplicillium sp. FKI-5985, were reported to have potent synergism with aminoglycoside antibiotics. Herein, we show that structural simplification expedites the synthesis...

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Cite This Study

LeBlanc et al. (2026) studied this question.

synapsesocial.com/papers/6a362ee4db0793dc1a536763 https://doi.org/10.1039/d6sc04046b

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Concise Synthesis of Simplified Aogacillin Analogs Reveals Innate Reactivity and Synergy with Aminoglycosides

Key Points

Implication

Abstract

Discussion

Cite This Study

Concise Synthesis of Simplified Aogacillin Analogs Reveals Innate Reactivity and Synergy with Aminoglycosides

Key Points

Implication

Abstract

Discussion

Cite This Study

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