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June 20, 2026Journal of Hepatocellular CarcinomaOpen Access

Intratumoral Fibrosis is a Potential Biomarker in Patients with Hepatocellular Carcinoma Undergoing Liver Resection

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Authors

DQDeng Qi-yuanTWTian-Cheng WangKYKun Ye

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Overview

Randomized trial evaluates intratumoral fibrosis as a prognostic biomarker in HCC patients, suggesting its potential for improving outcomes.

Key Points

  • This study aims to validate intratumoral fibrosis as a prognostic biomarker in hepatocellular carcinoma undergoing liver resection.
  • Enrolled 367 patients diagnosed with HCC undergoing liver resection.
  • Classified patients into high- and low-ITF groups using Sirius red staining.
  • Conducted Cox proportional hazards regression and propensity score matching to assess outcome predictors.
  • High-ITF patients had significantly shorter disease-free survival (DFS) and overall survival (OS) compared to low-ITF patients (P<0.05).
  • Factors significantly associated with early HCC recurrence included high-ITF, liver cirrhosis, serology markers, and tumor architecture (P<0.001).
  • High-ITF tumors were associated with a higher microvascular density (54.0 vs. 45.0, P<0.001).

Cite This Study

Qi-yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a362f11db0793dc1a536a32https://doi.org/10.2147/jhc.s608858
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