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June 20, 2026ACS Central ScienceOpen Access

Polymer-Coated Nanoarchitectonics of Titanium Dioxide Nanoparticles with Enhanced Antimicrobial Activity: Mechanistic Insights into Localized Particle–Membrane Interactions

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Authors

NANizar B. AlsharifLCLucrezia CaselliATAnders Thapper

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Overview

Randomized trial shows improved antimicrobial effects of polymer-coated titanium dioxide nanoparticles, indicating significant particle-membrane interactions.

Key Points

  • This research investigates how polymer coating influences the antimicrobial activity of titanium dioxide nanoparticles through particle-membrane interactions.
  • Coating of titanium dioxide nanoparticles with qPDMAEMA polymer for enhanced interactions with bacteria.
  • Assessment of particle adsorption on negatively charged bacterial membranes and associated membrane permeabilization upon UV exposure.
  • Studying localization effects using giant vesicles containing cardiolipin to analyze binding patterns.
  • Coated TiO2 nanoparticles significantly increased adsorption to bacterial membranes compared to bare TiO2.
  • Localized formation of reactive oxygen species was confirmed near membrane-bound nanoparticles, enhancing membrane disruption.
  • Experimental results indicated preferential binding of the coated nanoparticles to cardiolipin-rich membrane regions.

Cite This Study

Alsharif et al. (2026) studied this question.

synapsesocial.com/papers/6a362f11db0793dc1a536a8ehttps://doi.org/10.1021/acscentsci.6c00511
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