What question did this study set out to answer?

The aim is to highlight the underrecognition of metabolic causes, specifically nonhepatic hyperammonemia, in acute psychiatric presentations during pregnancy.

June 20, 2026Telangana Journal of PsychiatryOpen Access

Stress-triggered nonhepatic hyperammonemia presenting as acute psychiatric deterioration and evolving encephalopathy in pregnancy: A metabolic blind spot in perinatal psychiatry

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Authors

CMC. N. MeghaInstitute of Medical Sciences KKK. Kiran KumarInstitute of Medical Sciences KMKollipara Guna Sekhar MoorthyInstitute of Medical Sciences

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Implication

Case report demonstrates acute psychiatric deterioration in pregnancy due to metabolic causes, suggesting early recognition is crucial.

Key Points

The aim is to highlight the underrecognition of metabolic causes, specifically nonhepatic hyperammonemia, in acute psychiatric presentations during pregnancy.
Case report involving a 22-week pregnant woman with acute psychiatric symptoms attributed to metabolic disturbance.
Investigations included plasma ammonia measurement and neuroimaging (MRI) to rule out other etiologies.
Management encompassed lactulose therapy, dietary modification, and short-term pharmacotherapy for agitation.
Plasma ammonia levels decreased from 111 to 14 μmol/L following management.
Clinical improvement was observed with a reduction in neuropsychiatric symptoms.
Diagnosis of probable nonhepatic hyperammonemia was made despite a lack of confirmatory metabolic tests.

Cite This Study

Megha et al. (2026) studied this question.

synapsesocial.com/papers/6a362f3bdb0793dc1a536c82 https://doi.org/10.4103/tjp.tjp_20_26

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Stress-triggered nonhepatic hyperammonemia presenting as acute psychiatric deterioration and evolving encephalopathy in pregnancy: A metabolic blind spot in perinatal psychiatry

Discussion

Member takes

Implication

Key Points

Cite This Study

Stress-triggered nonhepatic hyperammonemia presenting as acute psychiatric deterioration and evolving encephalopathy in pregnancy: A metabolic blind spot in perinatal psychiatry

Discussion

Member takes

Implication

Key Points

Cite This Study

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