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June 20, 2026Current Neuropharmacology

The Microbiota-Gut-Brain Axis: A New Frontier in Precision Neuropsychopharmacology

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Authors

FEFrancisco Epelde

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Overview

Narrative review synthesizes mechanisms of gut microbiota on psychotropic drug outcomes, suggesting clinical relevance.

Key Points

  • This review aims to synthesize evidence on how gut microbiota influences psychotropic drug absorption, metabolism, and efficacy.
  • Conducted a narrative review of preclinical and clinical studies from PubMed, Scopus, and Web of Science.
  • Integrated findings from microbiology, neuroscience, pharmacology, and psychiatry, focusing on microbiota-drug interactions.
  • Explored effects of gut microorganisms on antidepressants, antipsychotics, mood stabilizers, and anxiolytics.
  • Gut microbiota modulates psychotropic drug effects via enzymatic biotransformation and neurotransmitter regulation.
  • Variability in microbiota composition correlates with differences in therapeutic response and tolerability.
  • Microbiota-targeted strategies, such as probiotics and dietary changes, show promise for enhancing drug efficacy and minimizing side effects.

Cite This Study

Francisco Epelde (2026) studied this question.

synapsesocial.com/papers/6a362f63db0793dc1a536d64https://doi.org/10.2174/011570159x438648260611062058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The gut–brain axis in pharmacology: microbiome-driven modulation of CNS drugs and neuropsychiatric outcomes2026
  2. 2Pharmacological interventions targeting the gut–brain axis in neurological disorders: mechanisms and translational applications2026 · 3 citations
  3. 3The emerging role of the microbiota–gut–brain axis in neuropsychiatric disorders: a narrative review2026
  4. 4Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders2024 · 84 citations
  5. 5Gut Microbiota in Psychiatric and Neurological Disorders: Current Insights and Therapeutic Implications2025 · 20 citations