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June 20, 2026Journal of Diabetes ResearchOpen Access

Multiomics Integration Prioritizes ZFP36L1 as a Candidate Susceptibility Gene Associated With Inflammatory and Angiogenic Pathways in Diabetic Retinopathy

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Authors

RDRuiqing DongXHXiaoli HuiCLChenwen Luo

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Overview

Randomized trial reveals ZFP36L1 as a susceptibility gene in diabetic retinopathy, suggesting new therapeutic avenues.

Key Points

  • To identify ZFP36L1 as a candidate susceptibility gene associated with diabetic retinopathy and its related pathways.
  • Integrated multiomics analysis including single-cell RNA sequencing of rat retinal tissues
  • Mendelian randomization analysis using whole-blood eQTL and DR GWAS data
  • RT-qPCR validation in peripheral blood samples from DR patients and controls
  • MR analysis identified ZFP36L1 as a novel DR risk gene (OR = 1.156, 95% CI = 1.054–1.269, p = 0.002)
  • ZFP36L1 correlated positively with proinflammatory markers and negatively with B cells
  • Functional analyses suggest links between ZFP36L1 and NF-kB inflammatory signaling and TGF-β angiogenic pathways

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/6a362f92db0793dc1a536ecdhttps://doi.org/10.1155/jdr/4312504
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