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June 20, 2026Blood AdvancesOpen Access

Outcomes of Adolescents and Young Adults with AML Treated on Pediatric vs Adult Protocols

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Authors

BKBaher KrayemJBJeetayu BiswasADAndriy Derkach

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Overview

Retrospective study examines survival outcomes in adolescents and young adults with AML treated under pediatric and adult protocols, suggesting adult regimens may offer better survival rates.

Key Points

  • This study aims to compare treatment outcomes of adolescents and young adults with AML on pediatric versus adult protocols.
  • Single-center retrospective study of 81 AYA patients aged 14-29 with newly diagnosed AML
  • Patients analyzed based on treating service and induction regimens
  • Treatment included pediatric ADE-based induction and adult 7+3 induction followed by consolidation.
  • Five-year overall survival was better for adult-service patients (77.9%) than for pediatric patients (56.7%)
  • Complete response rates were similar between groups (79% adult vs 78% pediatric)
  • ELN 2022 risk category remained an independent prognostic factor, while treatment protocol did not.

Cite This Study

Krayem et al. (2026) studied this question.

synapsesocial.com/papers/6a362f92db0793dc1a536ee1https://doi.org/10.1182/bloodadvances.2026020372
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Also Consider

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