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This research aims to improve the reference genome assembly of Caenorhabditis briggsae to facilitate better comparative studies.

A gap-free, telomere-to-telomere genome assembly for the Caenorhabditis briggsae reference strain AF16

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This research aims to improve the reference genome assembly of Caenorhabditis briggsae to facilitate better comparative studies.
Utilized high-coverage long-read sequencing and chromosome conformation capture data for genome assembly.
Created an updated reference genome named CGC2 that is free of gaps and unplaced sequences.
Predicted protein-coding gene annotations using RNA-seq libraries and lifted over insertion-deletion variants.
The CGC2 genome assembly is completed with telomere-to-telomere contiguity, enhancing the genomic landscape.
Achieved greater accuracy and completeness in gene model predictions compared to existing AF16 annotations.
Facilitated future genetic variant mapping by validating and lifting over 108 insertion-deletion variants.

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Randomized trial updates the reference genome and enhances resources for Caenorhabditis briggsae, supporting comparative genomics.

O'Connor et al. (2026) studied this question.

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