Review summarizes polymeric nanoparticle therapies enhancing drug delivery efficacy in head and neck cancers, indicating potential improvements.
Key Points
This review aims to summarize advances in polymer-based therapies for head and neck cancer and their mechanisms of action. It explores how engineered nanoparticles can improve treatment outcomes.
Reviewed advances in polymeric nanoparticle systems including PCL, PLGA, chitosan, and polyethyleneimine for HNC.
Highlighted applications of these nanoparticles in chemotherapy, gene therapy, and phototherapies.
Discussed mechanisms including apoptosis induction and enhanced drug release for major cancer types like OSCC and nasopharyngeal cancers.
PCL nanoparticles demonstrated tumor growth inhibition and effective dual drug delivery with phototherapy in OSCC.
PLGA formulations showed enhanced release and efficacy of chemotherapeutics like paclitaxel and cisplatin in nasopharyngeal cancers.
Chitosan systems provided improved drug residence time and effective gene silencing at mucosal sites.